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Focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti infective drug discoverynatural products are an extremely important source of new drug leads as the number of bacterial strains resistant to current therapeutics increases the need for molecules with novel modes of actiontotal synthesis of natural products with antimicrobial activity springer theses view larger image by andrew giltrap sign up now already a member log in you must be logged into bookshare to access this title learn about membership options or view our freely available titlesget this from a library total synthesis of natural products with antimicrobial activity andrew giltrap this thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti infective drug discovery it describes the total abstract the synthesis of deshydroxy skyllamycins ac 116118 described in the previous chapter laid the foundation for the synthesis of the native natural products skyllamycins ac 101103while a number of synthetic challenges were overcome during the synthesis of deshydroxy skyllamycins ac 116118 the installation of the unusual oh gly residue was not investigated

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